Current ATS/CDC/ERS/IDSA consolidated guidelines on treating drug-resistant TB

 As per MDR-TB
INH-resistant TB
 RIF+PZA+ETM+FLQ for 6 months (can discontinue PZA after 2 months; FLQ only required in patients with extensive disease, i.e. cavitary or bilateral infiltrates)
 First lineLevofloxacin or Moxifloxacin with all 4 of: Bedaquiline + Linezolid + Clofazimine# + Cycloserine#
 Second lineConsider Delamanid2 or Pyrazinamide3 or Ethambutol1 or Amikacin or Streptomycin5
 Third lineConsider ETH6 or Prothionamide or Imipenem-Cilastatin/Clavulante or Meropenem/Clavulanate4 or p-Aminosalicylic Acid7 or High Dose Isoniazid

ATS: American Thoracic Society; CDC: US Centers For Disease Control And Prevention; ERS: European Respiratory Society; IDSA: Infectious Diseases Society of America. #: in contrast, the WHO suggests only one of these drugs are required, comprising a 4-drug regimen (see text for full details); : superscript numbers refer to the order in which the WHO suggests drugs be incorporated into regimes. Information from [50].