Unpooled analysis of least squares mean change in FEV1 from baseline to week 24
| FF/VI 100/25 µg plus | FF/VI 200/25 µg plus | |||||
| No UMEC | UMEC 31.25 µg | UMEC 62.5 µg | No UMEC | UMEC 31.25 µg | UMEC 62.5 µg | |
| Subjects n | 379 | 381 | 390 | 385 | 384 | 391 |
| Changes from baseline in trough FEV1 mL at week 24 | 24 (−6–55) | 120 (89–151) | 134 (104–165) | 76 (45–106) | 157 (127–188) | 168 (137–198) |
| Changes in FEV1 mL by adding UMEC at week 24 | Ref. | +96 (52–139) p<0.0001 | +110 (66–153) p<0.0001 | Ref. | +82 (39–125) p<0.0002 | +92 (49–135) p<0.0001 |
Data are presented as least squares mean (95% CI), unless otherwise stated. The p-values are not adjusted for multiplicity.