General characteristics of the participants included in the randomised controlled trials assessing the effects of continuous positive airway pressure (CPAP) treatment on cardiovascular morbimortality

SAVE study [12]RICCADSA study [13]ISAACC study [15]
Inclusion criteriaModerate-severe OSA (ODI ≥12 events·h−1)Moderate-severe OSA (AHI ≥15 events·h−1)Moderate-severe OSA (AHI ≥15 events·h−1)
Coronary artery disease or cerebrovascular diseaseCoronary artery diseaseAcute coronary syndrome
Exclusion criteriaSevere daytime sleepiness (ESS >15/24)Excessive daytime sleepiness (ESS ≥10/24)Excessive daytime sleepiness (ESS >10/24)
Age, years616660
Men, %818584
AHI, events·h−1312936
Number of events, n (%)CPAP: 229 (17%)CPAP: 22 (18%)CPAP: 98 (16%)
Usual care: 207 (15%)Usual care: 27 (22%)Usual care: 108 (17%)
CPAP use, mean±sd, h per night3.3±2.3Not stated2.8±2.7

Age, ESS, AHI are presented as the mean values for the study cohort. AHI: apnoea–hypopnoea index; ESS: Epworth sleepiness scale; ODI: oxygen desaturation index; OSA: obstructive sleep apnoea.