General characteristics of the participants included in the randomised controlled trials assessing the effects of continuous positive airway pressure (CPAP) treatment on cardiovascular morbimortality
| SAVE study [12] | RICCADSA study [13] | ISAACC study [15] | |
| Inclusion criteria | Moderate-severe OSA (ODI ≥12 events·h−1) | Moderate-severe OSA (AHI ≥15 events·h−1) | Moderate-severe OSA (AHI ≥15 events·h−1) |
| Coronary artery disease or cerebrovascular disease | Coronary artery disease | Acute coronary syndrome | |
| Exclusion criteria | Severe daytime sleepiness (ESS >15/24) | Excessive daytime sleepiness (ESS ≥10/24) | Excessive daytime sleepiness (ESS >10/24) |
| Age, years | 61 | 66 | 60 |
| Men, % | 81 | 85 | 84 |
| ESS | 7.4 | 5.5 | 5.2 |
| AHI, events·h−1 | 31 | 29 | 36 |
| Number of events, n (%) | CPAP: 229 (17%) | CPAP: 22 (18%) | CPAP: 98 (16%) |
| Usual care: 207 (15%) | Usual care: 27 (22%) | Usual care: 108 (17%) | |
| CPAP use, mean±sd, h per night | 3.3±2.3 | Not stated | 2.8±2.7 |
Age, ESS, AHI are presented as the mean values for the study cohort. AHI: apnoea–hypopnoea index; ESS: Epworth sleepiness scale; ODI: oxygen desaturation index; OSA: obstructive sleep apnoea.