Case ReportCystic fibrosis presenting with intracerebral haemorrhage
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Cited by (17)
Vitamin K and cystic fibrosis: A gordian knot that deserves our attention
2019, Respiratory MedicineCitation Excerpt :CF can only occasionally present as a bleeding disorder secondary to VK deficiency. Manifestations may include mucosal and subcutaneous bleeding or, especially in the first months of life, a more severe bleeding disorder such as intracerebral hemorrhage [74–76]. The uncommonness of the problem probably reflects the ability of the liver to absorb efficiently and use effectively circulating VK [77].
Hematologic Manifestations of Childhood Illness
2018, Hematology: Basic Principles and PracticeHematologic Manifestations of Childhood Illness
2017, Hematology: Basic Principles and PracticeCoagulation Disorder as a Presentation of Cystic Fibrosis
2010, Journal of Emergency MedicineCitation Excerpt :Most case reports of coagulation disorders as disease-presenting manifestations of CF are remote, and many were published before the routine use of post-natal vitamin K. Torstenson et al. reported on three cases of infants with CF who presented with acute hemorrhage due to vitamin K malabsorption in 1970 (8). Merelle et al. reported on an infant with CF who presented for medical attention with hematomas and intracerebral hemorrhage (11). Ter Avest et al. reported on 2 patients who presented with coagulopathies as their initial CF disease-presenting manifestations, one with hemolytic anemia secondary to vitamin E deficiency and the other with multiple hematomas secondary to vitamin K deficiency (12).
Bleeding diathesis due to vitamin K deficiency in an infant with cystic fibrosis
2010, Respiratory Medicine CMECitation Excerpt :Coagulopathy in infancy is a rare presentation of CF with a few recent cases described in the English literature. CF infants 2–3.5 months of age with manifestation of intracranial hemorrhage3,9 and bruising and hematomas 10,11 have been described. We report on an infant with newly diagnosed CF through NBS, presenting with severe bleeding diathesis, manifesting as gastrointestinal bleeding.
Cystic fibrosis in neonates and infants
2005, Early Human Development