Risk factors for cardiovascular events in hospitalized patients with community-acquired pneumonia

https://doi.org/10.1016/j.ijid.2013.07.005Get rights and content
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Summary

Background

An increased risk of cardiovascular complications has been found in those with community-acquired pneumonia (CAP). Preliminary data suggest that pneumococcal pneumonia, more severe pneumonia, older age, renal disease, hypoalbuminemia, and inpatient sliding scale insulin administration contribute to risk. The objective of this study was to ascertain additional factors influencing cardiovascular events in CAP.

Methods

This investigation was a retrospective cohort study of inpatients with CAP. Outcomes evaluated were development of a cardiovascular event during hospitalization, defined as acute pulmonary edema, cardiac arrhythmia, or myocardial infarction. Those with and without events were compared across cardiovascular- and pneumonia-specific variables by logistic regression to ascertain factors that independently increase risk or reduce risk.

Results

Of 3068 inpatients with pneumonia, 376 (12%) developed a cardiovascular event. Hyperlipidemia, more severe pneumonia, and Staphylococcus aureus or Klebsiella pneumoniae as etiologies were associated with increased risk, while statin use was associated with decreased risk.

Conclusions

This study highlights variables in CAP patients that should make clinicians vigilant for the development of cardiac complications. Additional research is needed to determine if statins attenuate cardiac risk in CAP.

Keywords

Community-acquired pneumonia
Cardiovascular risk factors

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