Asthma diagnosis and treatmentEffects of a leukotriene receptor antagonist on exhaled leukotriene E4 and prostanoids in children with asthma
Section snippets
Study subjects
Two groups of children were included in the montelukast study: 18 white atopic children with stable mild intermittent asthma and 18 atopic children without asthma. Seventeen atopic children with asthma and 16 atopic children without asthma completed the study (Table I; see the Methods section in the Online Repository at www.jacionline.org). Atopic children were recruited from the Allergy Outpatient Clinic of the Istituto Dermopatico dell'Immacolata, Rome, Italy, and the Asthma and Allergy
Results
No α-amylase concentrations were detected in any study sample, excluding gross salivary contamination.
Discussion
We sought to investigate the effect of montelukast on exhaled LTE4, 8-isoprostane, and PGE2 in atopic children with and without asthma. In the current study, median exhaled LTE4 values were decreased by 33% after montelukast in children with asthma, whereas treatment had no effect on exhaled LTE4 in atopic children without asthma. Montelukast had no effect on exhaled 8-isoprostane and PGE2 in both groups of children. In children with asthma, there was a strong correlation between reduction in
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Supported by the Catholic University of the Sacred Heart, Rome, Italy academic grant 2004-2005.
Disclosure of potential conflict of interest: P. J. Barnes has received grant support from GlaxoSmithKline, AstraZeneca, Pfizer, Novartis, and Boehringer-Ingelheim, and is on the advisory board for GlaxoSmithKline, Pfizer, Boehringer-Ingelheim, and Altana. The rest of the authors have declared that they have no conflict of interest.