Asthma and lower airway diseaseBiomarker-based asthma phenotypes of corticosteroid response
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Supported by Lottery Health New Zealand, the Dunedin School of Medicine, National Institutes of Health grants HL1034531 and HL109250, and Alfred Lerner Memorial Chair (to S.C.E.). S.C.E. is a Senior Fellow of the American Asthma Foundation. S.L.H. was partially supported by a gift from the Leonard Krieger Fund. Mass spectrometry instrumentation used for BrTyr analyses is housed within the Cleveland Clinic Lerner Research Institute Mass Spectrometry Facility, which is partially supported by a Center of Innovation Award by AB Sciex.
Disclosure of potential conflict of interest: S. L. Hazen reports grants from the National Institutes of Health (P01HL103453), nonfinancial support from Abbott, grants and personal fees from the Cleveland Heart Lab, personal fees from Esperion, grants from Foundation LeDucq, personal fees from Frantz Biomarkers, personal fees from Lilly, grants and personal fees from Liposcience, personal fees from Merck & Co, grants and personal fees from Pfizer, grants and personal fees from Procter & Gamble, personal fees from Siemens, and grants from Takeda Pharmaceuticals during the conduct of the study. In addition, S. L. Hazen has a patent with Cleveland Clinic and is partially supported by a gift from the Leonard Krieger endowment. The rest of the authors declare that they have no relevant conflicts of interest.
Trial Registration: Australian New Zealand Clinical Trials Registry ACTRN12606000531516, ACTRN12606000488505.