Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Viral Infections

Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation

Bone Marrow Transplantation volume 31, pages 481–486 (2003)Cite this article

Summary:

Adenovirus is an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation and there is no established therapy. Cidofovir has in vitro efficacy against adenovirus. We performed a retrospective analysis of 45 patients treated with cidofovir for adenovirus from 10 centers. In total, 16 patients had definite adenovirus disease, 13 probable disease, and 16 asymptomatic infections. A total of 31 (69%) patients were successfully treated with cidofovir, 10 failed, and four were not evaluable owing to early death from other causes. Cidofovir therapy was successful in 10 patients with adenovirus disease, 10 patients with probable disease, and in 10 patients with asymptomatic infections. The overall survival at 28 days and 6 months after initiation of cidofovir therapy was 76 and 46%, respectively. Of the patients, 18 developed toxicity associated with cidofovir: 14 developed renal toxicity and four other types of toxicities. We conclude that cidofovir may be useful against adenovirus after allogeneic hematopoietic stem cell transplantation but additional studies are needed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Hale GA, Heslop HE, Krance RA et al. Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transplant 1999; 23: 277–282.

    Article  CAS  PubMed  Google Scholar 

  2. Howard DS, Phillips GL, Reece DE et al. Adenovirus infections in hematopoietic stem cell transplant recipients. Clin Infect Dis 1999; 29: 1494–1501.

    Article  CAS  PubMed  Google Scholar 

  3. Flomenberg P, Babbitt J, Drobyski WR et al. Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis 1994; 169: 775–781.

    Article  CAS  PubMed  Google Scholar 

  4. Baldwin A, Kingman H, Darville M et al. Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation. Bone Marrow Transplant 2000; 26: 1333–1338.

    Article  CAS  PubMed  Google Scholar 

  5. De Clercq E . Therapeutic potential of Cidofovir (HPMPC, Vistide) for the treatment of DNA virus (i.e. herpes-, papova-, pox- and adenovirus) infections. Verh K Acad Geneeskd Belg 1996; 58: 19–47; discussion 47–49.

    CAS  PubMed  Google Scholar 

  6. de Oliveira CB, Stevenson D, LaBree L et al. Evaluation of Cidofovir (HPMPC, GS-504) against adenovirus type 5 infection in vitro and in a New Zealand rabbit ocular model. Antivir Res 1996; 31: 165–172.

    Article  CAS  PubMed  Google Scholar 

  7. Ljungman P, Deliliers GL, Platzbecker U et al. Cidofovir for cytomegalovirus infection and disease in allogeneic stem cell transplant recipients. The Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Blood 2001; 97: 388–392.

    Article  CAS  PubMed  Google Scholar 

  8. La Rosa AM, Champlin RE, Mirza N et al. Adenovirus infections in adult recipients of blood and marrow transplants. Clin Infect Dis 2001; 32: 871–876.

    Article  CAS  PubMed  Google Scholar 

  9. Wasserman R, August CS, Plotkin SA . Viral infections in pediatric bone marrow transplant patients. Pediatr Infect Dis J 1988; 7: 109–115.

    Article  CAS  PubMed  Google Scholar 

  10. Shields AF, Hackman RC, Fife KH et al. Adenovirus infections in patients undergoing bone-marrow transplantation. N Engl J Med 1985; 312: 529–533.

    Article  CAS  PubMed  Google Scholar 

  11. Chakrabarti S, Collingham KE, Fegan CD et al. Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy. Bone Marrow Transplant 1999; 23: 1209–1211.

    Article  CAS  PubMed  Google Scholar 

  12. Miyamura K, Hamaguchi M, Taji H et al. Successful ribavirin therapy for severe adenovirus hemorrhagic cystitis after allogeneic marrow transplant from close HLA donors rather than distant donors. Bone Marrow Transplant 2000; 25: 545–548.

    Article  CAS  PubMed  Google Scholar 

  13. Mann D, Moreb J, Smith S et al. Failure of intravenous ribavirin in the treatment of invasive adenovirus infection following allogeneic bone marrow transplantation: a case report. J Infect 1998; 36: 227–278.

    Article  CAS  PubMed  Google Scholar 

  14. Cassano WF . Intravenous ribavirin therapy for adenovirus cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant 1991; 7: 247–248.

    CAS  PubMed  Google Scholar 

  15. Liles WC, Cushing H, Holt S et al. Severe adenoviral nephritis following bone marrow transplantation: successful treatment with intravenous ribavirin. Bone Marrow Transplant 1993; 12: 409–412.

    CAS  PubMed  Google Scholar 

  16. Hromas R, Clark C, Blanke C et al. Failure of ribavirin to clear adenovirus infections in T cell-depleted allogeneic bone marrow transplantation. Bone Marrow Transplant 1994; 14: 663–664.

    CAS  PubMed  Google Scholar 

  17. Kapelushnik J, Or R, Delukina M et al. Intravenous ribavirin therapy for adenovirus gastroenteritis after bone marrow transplantation. J Pediatr Gastroenterol Nutr 1995; 21: 110–112.

    Article  CAS  PubMed  Google Scholar 

  18. Bordigoni P, Carret AS, Venard V et al. Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 2001; 32: 1290–1297.

    Article  CAS  PubMed  Google Scholar 

  19. Ribaud P, Scieux C, Freymuth F et al. Successful treatment of adenovirus disease with intravenous cidofovir in an unrelated stem-cell transplant recipient. Clin Infect Dis 1999; 28: 690–691.

    Article  CAS  PubMed  Google Scholar 

  20. Legrand F, Berrebi D, Houhou N et al. Early diagnosis of adenovirus infection and treatment with cidofovir after bone marrow transplantation in children. Bone Marrow Transplant 2001; 27: 621–626.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This study was supported by Karolinska Institute, the Swedish Cancer Society and the Swedish Children's Cancer Foundation.

Author information

Authors and Affiliations

  1. Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden

    P Ljungman

  2. Hôpital St Louis, Paris, France

    P Ribaud

  3. University Hospital, Tübingen, Germany

    M Eyrich

  4. St Anna Kinder Hospital, Vienna, Austria

    S Matthes-Martin

  5. University Children's Hospital, Tübingen, Germany

    H Einsele

  6. New Children's Hospital, Sydney, Australia

    M Bleakley

  7. Jagiellonian University, Krakow, Poland

    M Machaczka

  8. University Hospital, Utrecht, The Netherlands

    M Bierings

  9. University Hospital, Firenze, Italy

    A Bosi

  10. Hôpital de l'Archet, Nice, France

    N Gratecos

  11. Hôpital Henri Mondor, Creteil, France

    C Cordonnier

Authors
  1. P Ljungman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P Ribaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M Eyrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S Matthes-Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H Einsele
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M Bleakley
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M Machaczka
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M Bierings
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A Bosi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. N Gratecos
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. C Cordonnier
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ljungman, P., Ribaud, P., Eyrich, M. et al. Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 31, 481–486 (2003). https://doi.org/10.1038/sj.bmt.1703798

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703798

Keywords

This article is cited by

Search

Advanced search

Quick links