Clinical–Alimentary TractUveitis and erythema nodosum in inflammatory bowel disease: Clinical features and the role of HLA genes☆,☆☆
Section snippets
Patient selection
The case notes of 976 UC patients and 483 Crohn's disease patients attending the Oxford Inflammatory Bowel Disease Clinic were reviewed as previously described,12 and information on the general nature of the bowel disease and EIMs was obtained. This information was validated by a questionnaire regarding EIMs administered in the Outpatient department at routine follow-up visits. All patients who had suffered from AS, peripheral arthritis, EN, or acute ocular inflammation were identified from the
Clinical features
There were 39 patients with EN (29 of 483 Crohn's disease [6%] and 10 of 976 UC [1%]) and 50 patients with ocular inflammation (25 of 483 Crohn's disease [5%] and 25 of 976 UC [3%]). The clinical features of EN and ocular complications are shown in Table 1.Empty Cell Erythema nodosum (n = 39) Ocular inflammation (n = 50) Female:male ratio 33:6 (5.5:1) 35:15 (2.3:1) Present at or before diagnosis (%) 20 (51) 11 (22) Related to IBD activity (%) 36 (92) 39 (78) Recurrent
Discussion
This study delineates clearly the clinical features of EN and acute ocular inflammation in IBD. They are both more common in women (strikingly so in the case of EN) and are both associated with active gut disease. EN is associated with the presence of colonic Crohn's disease, but there is no association with site of disease in uveitis or in EN associated with UC.
EN is nearly always self-limiting, with a maximum duration of 12 weeks in this population. In addition, after acute ocular
References (18)
- et al.
The prevalence of extraintestinal diseases in inflammatory bowel disease: a population based study
Am J Gastroenterol
(2001) - et al.
National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications
Gastroenterology
(1979) - et al.
Ocular inflammation in Crohn's disease
Ophthalmology
(1991) - et al.
A shared and unique peptide in the human colon, eye, and joint detected by a monoclonal antibody
Gastroenterology
(1994) - et al.
Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease
Gastroenterology
(2000) - et al.
Extra-intestinal complications of Crohn's disease and ulcerative colitis
Medicine
(1976) - et al.
Clinical features of erythema nodosum (EN) and uveitis assocaited with inflammatory bowel disease (abstr)
Gastroenterology
(2000) - et al.
Immune-related systemic manifestations of inflammatory bowel disease. A prospective study of 792 patients
J Clin Gastroenterol
(1996) - et al.
Selected rheumatologic and dermatologic manifestations of inflammatory bowel disease
Am J Gastroenterol
(1988)
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Address requests for reprints to: Timothy Orchard, M.D., University of Oxford, Woodstock Road, Oxford OX2 6HE, United Kingdom. e-mail: [email protected]; fax: (44) 207-886-1138.
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Supported partly by the Arthritis Research Campaign (ARC; to T.R.O.) and by the National Association for Colitis and Crohn's disease (NACC; to T.A.).