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Original ResearchBRONCHIECTASISFactors Associated With Lung Function Decline in Adult Patients With Stable Non-Cystic Fibrosis Bronchiectasis
Section snippets
Study Population
We studied all patients with bronchiectasis that had been diagnosed in our center (Hospital de Requena; Valencia, Spain), affecting more than one lung lobe, or with cystic bronchiectasis, unrelated to CF and in a clinically stable phase (ie, subjects had been free from acute exacerbation for at least 4 weeks prior to the start of the study). Exclusion criteria were as follows: current smokers; patients with a smoking history of > 10 pack-years; patients at occupational risk for COPD; patients
Patients
Of 112 patients with bronchiectasis, who were never-smokers or had a smoking history of < 10 pack-years, we excluded 23 patients with suspected asthma, 5 patients with mental or physical impairments that prevented them from completing the study protocol, and 6 patients with unacceptable quality spirometry results. Two patients refused to participate in the study. The baseline characteristics of the 76 participants (48.7% men; mean age, 69.9 years; age range, 39 to 83 years) included in the
Discussion
Our study, using a well-characterized cohort with stable, non-CF bronchiectasis, has shown for the first time that chronic sputum colonization with PA, more frequent severe exacerbations, and more systemic inflammation are independent factors associated with a faster decline of lung function. Regrettably, none of the long-term treatment strategies evaluated, including use of long-acting inhaled bronchodilators, inhaled or oral steroids, oxygen therapy, or antibiotics had a lasting, significant
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This study has been supported in part by a grant (Redrespira-ISCiii-RTIC-03/11) from the Spanish Ministry of Health.
Dr. Soriano was an employee of GlaxoSmithKline from 1998 to 2005 (see financial disclosure form). Drs. Martínez-García, Soler-Cataluña, Perpiña-Tordera, and Román-Sánchez have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.