Chest
Original ResearchIdiopathic Pulmonary FibrosisIncidence, Prevalence, and Clinical Course of Idiopathic Pulmonary Fibrosis: A Population-Based Study
Section snippets
Study Design and Settings
Following approval from the Mayo Foundation and Olmsted Medical Center Institutional Review Board, we conducted a community-based historical cohort study of IPF in Olmsted County (Fig 1). Population-based research is feasible in Olmsted County through the use of the unique resources of the Rochester Epidemiology Project (REP), a medical record linkage system for health-care providers to residents of Olmsted County.13, 14 Medical care is essentially self-contained within this community of
Results
During the 9-year study period, 596 Olmsted County residents aged 18 years or older were initially screened and identified to have possible pulmonary fibrosis (89% > 50 years old). After review of the medical records, 499 patients were excluded because they did not have idiopathic interstitial pneumonia (eg, chronic pulmonary infections), 42 had a known cause for pulmonary fibrosis (eg, connective tissue disease), three had an unlikely UIP pattern on CT image (with no lung biopsy), and five had
Discussion
To our knowledge, this is the first population-based study that provides an epidemiologic update of trends from the recent years in a general population of patients with IPF using ATS/ERS diagnostic criteria. We found that the adjusted incidence rate of IPF decreased during the 9-year study period, with peaks in 1998 and 2001.
The cause of the two distinct peaks observed in IPF incidence rate (1998 and 2001) is uncertain. Several explanations exist and include a reduction in disease latency
Acknowledgments
Author contributions: Dr Fernández Pérez: performed the study conceptualization and design; assisted in data collection; worked on clinical, radiologic, and pathologic case characterization; performed statistical analyses; and assisted in manuscript preparation, revision, and final approval.
Dr. Daniels: worked on clinical, radiologic, and pathologic case characterization and assisted in manuscript preparation, revision, and final approval.
Mr Schroeder: assisted in data collection; performed
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An abstract of this study was presented at the American College of Chest Physicians 74th Congress, October 25–30, 2008, Philadelphia, Pennsylvania.
Funding/support: This study was made possible by the Rochester Epidemiology Project (Grant R01-AR30582 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases).
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).