Chest
Clinical InvestigationsCOPDThe Proportional Venn Diagram of Obstructive Lung Disease*: Two Approximations From the United States and the United Kingdom
Section snippets
Data Sources
We analyzed data from the US National Health and Nutrition Examination (NHANES) III survey, conducted from 1988 to 1994, and the UK General Practice Research Database (GPRD) for the year 1998.
The NHANES III was a cross-sectional, multistage probability sample (n = 33,994) that was representative of the total noninstitutionalized civilian population of the United States, and surveys were conducted from 1988 to 1994.78 Information about the medical history of respiratory symptoms and diagnoses of
Results
The descriptive characteristics of NHANES III and GPRD participants with OLD are presented in Table 1. Patients were stratified into seven mutually exclusive disease groups by age and sex for each study population. Patients with asthma, in whom diagnoses had been made with or without other OLD conditions, were younger than COPD patients. The combination of asthma with chronic bronchitis, but not with emphysema, was associated with younger age.
In the US NHANES III total population, the
Discussion
Our analysis highlights the problem of the differential diagnosis among OLDs, particularly in older adults and the elderly. By analyzing large samples of patients from the general population in the United States and the United Kingdom, we demonstrated that a substantial number of patients are diagnosed with two or even all three OLD conditions concomitantly. By analyzing the NHANES III spirometry data, we observed that diagnoses of asthma, chronic bronchitis, and emphysema are present with and
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This study was supported by GlaxoSmithKline Research and Development.