Chest
Original Research: CYSTIC FIBROSISImpact of Pregnancy on Women With Cystic Fibrosis
Section snippets
Materials and Methods
We examined data from the ESCF that documented the clinical course and treatment of 24,000 individuals with CF living in the United States and Canada who were followed up for up to 9 years. Sites providing care for ≥ 10 patients with a documented diagnosis of CF who elected to participate obtained patient consent, as required by local investigational review boards, and collected data, including those on specific pulmonary and nutritional therapies for each patient encounter. All patient therapy
Results
A total of 216 women aged 15 to 38 years met the criteria for at least one qualifying pregnancy reported during the 9 years of the study (Fig 2). Single pregnancies occurred in 192 women (89%). The remaining 24 pregnancies included in this analysis represented multiple pregnancies (first pregnancy, 15 pregnancies; second pregnancy, 8 pregnancies; or third pregnancy, 1 pregnancy). The median age at the time of pregnancy was 24 years; three fourths of pregnancies occurred in women who were
Discussion
Because of improved health outcomes in patients with CF, an increasing number of affected women are interested in bearing children. Investigators have previously reported5, 6, 7, 89 that the outcomes associated with these pregnancies include healthy infants, a slight deterioration in maternal pulmonary function, and uncompromised long-term survival. Our findings are consistent with these reports and, in addition, show a substantial increase in therapy both during and after the pregnancy in
Conclusions
Analyses of data from this large cohort demonstrate that women with CF can experience a pregnancy with the impact on their overall respiratory and nutritional health being similar to nonpregnant women. Pregnant women with CF will likely require increased use of various therapies and more hospitalizations, and receive more intensive monitoring of their health. In addition, these women will have an increased chance of requiring treatment for diabetes both during and after pregnancy. There is also
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Cited by (86)
Pregnancy in cystic fibrosis: Review of the literature and expert recommendations
2022, Journal of Cystic FibrosisCitation Excerpt :As in the CF registry study by Goss et al., women who became pregnant had higher baseline lung function than those who did not become pregnant [50]. Given that the use of IV antibiotics did not increase during the same period, the authors believed pregnant women were being admitted more frequently for closer surveillance or for potential obstetric complications [47]. We, therefore, recommend that clinicians discuss the potential increase in clinic visits and antibiotics use that may occur during pregnancy as women are planning their pregnancies.
Gestational and pregestational diabetes in pregnant women with cystic fibrosis
2022, Journal of Clinical and Translational EndocrinologyChallenges Faced by Women with Cystic Fibrosis
2021, Clinics in Chest MedicineCystic fibrosis and pregnancy: Outcome, prognostic factors and obstetrical management
2020, Gynecologie Obstetrique Fertilite et SenologieCystic Fibrosis Foundation consensus guidelines for the care of individuals with advanced cystic fibrosis lung disease
2020, Journal of Cystic Fibrosis
Supported by Genentech, Inc., South San Francisco, CA.
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