Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis

Toshiaki Ohara; Takahiro Oto; Kentaro Miyoshi; Hiroyuki Tao; Masaomi Yamane; Shinichi Toyooka; Megumi Okazaki; Hiroshi Date; Yoshifumi Sano

doi:10.1016/j.athoracsur.2008.07.062

Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis

Ann Thorac Surg. 2008 Dec;86(6):e7-8. doi: 10.1016/j.athoracsur.2008.07.062.

Authors

Toshiaki Ohara¹, Takahiro Oto, Kentaro Miyoshi, Hiroyuki Tao, Masaomi Yamane, Shinichi Toyooka, Megumi Okazaki, Hiroshi Date, Yoshifumi Sano

Affiliation

¹ Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan.

PMID: 19021963
DOI: 10.1016/j.athoracsur.2008.07.062

Abstract

We report a successful case of sirolimus treatment for chylous pleural and peritoneal effusions of lymphangioleiomyomatosis after lung transplantation. A 32-year-old woman underwent living donor lung transplantation. Persistent chylous pleural and peritoneal effusions were seen postoperatively. Pleurodesis by intrathoracic injection of OK-432, minomycin, and somatostatine analog failed to control chylous effusions. However, sirolimus treatment reduced the amount of chylous drainage and improved both chylous pleural and peritoneal effusions.

Publication types

Case Reports

MeSH terms

Administration, Oral
Adult
Chylothorax / drug therapy*
Chylothorax / etiology
Chylous Ascites / drug therapy*
Chylous Ascites / etiology
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Immunosuppressive Agents / therapeutic use*
Lung Neoplasms / diagnosis
Lung Neoplasms / surgery
Lung Transplantation / adverse effects*
Lung Transplantation / methods
Lymphangioleiomyomatosis / diagnosis
Lymphangioleiomyomatosis / surgery
Postoperative Complications / diagnosis
Postoperative Complications / drug therapy
Risk Assessment
Sirolimus / therapeutic use*
Treatment Outcome

Substances

Immunosuppressive Agents
Sirolimus