Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves
the precision and sensitivity of evolutionary inference, producing more robust results than …

Drosophila melanogaster is one of the most well studied genetic model organisms; nonetheless,
its genome still contains unannotated coding and non-coding genes, transcripts, exons …

To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing
an ensemble of transcript isoforms that give rise to substantial diversity. Here we have …

High-throughput sequencing of cDNA (RNA-seq) is a widely deployed transcriptome profiling
and annotation technique, but questions about the performance of different protocols and …

Microarrays first made the analysis of the transcriptome possible, and have produced much
important information. Today, however, researchers are increasingly turning to direct high-…

Sex chromosomes are primary determinants of sexual dimorphism in many organisms. These
chromosomes are thought to arise via the divergence of an ancestral autosome pair and …

Intracellular neutral lipid storage droplets are essential organelles of eukaryotic cells, yet little
is known about the proteins at their surfaces or about the amino acid sequences that target …

The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid
tumours that plays a crucial role in shaping their progression. Many desmoplastic tumours …