Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

…, HR Lu, R Towart, DJ Gallacher… - Proceedings of the …, 2013 - National Acad Sciences
Cellular and ionic causes of variability in the electrophysiological activity of hearts from
individuals of the same species are unknown. However, improved understanding of this …

[HTML][HTML] Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity

…, J Rohrbacher, AN Hermans, DJ Gallacher… - Frontiers in …, 2017 - frontiersin.org
Early prediction of cardiotoxicity is critical for drug development. Current animal models
raise ethical and translational questions, and have limited accuracy in clinical risk prediction. …

Common respiratory conditions of the newborn

DJ Gallacher, K Hart, S Kotecha - Breathe, 2016 - Eur Respiratory Soc
Key points Respiratory distress is a common presenting feature among newborn infants.
Prompt investigation to ascertain the underlying diagnosis and appropriate subsequent …

A new biomarker–index of Cardiac Electrophysiological Balance (iCEB)–plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and …

HR Lu, GX Yan, DJ Gallacher - Journal of pharmacological and …, 2013 - Elsevier
Introduction In the present study, we investigated whether a new biomarker – index of
cardiac electrophysiological balance (iCEB = QT/QRS) – could predict drug-induced cardiac …

High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry

…, P Gehalot, A Savchenko, DJ Gallacher… - … of pharmacological and …, 2012 - Elsevier
Current methods to measure physiological properties of cardiomyocytes and predict fatal
arrhythmias that can cause sudden death, such as Torsade de Pointes, lack either the …

Evaluation of index of cardio‐electrophysiological balance (iCEB) as a new biomarker for the identification of patients at increased arrhythmic risk

…, DJ Gallacher, C Garweg, J Ector… - Annals of …, 2016 - Wiley Online Library
Background Recently a new risk marker for drug‐induced arrhythmias called index of cardio‐electrophysiological
balance (iCEB), measured as QT interval divided by QRS duration, …

In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome

DJ Gallacher, A Van de Water… - Cardiovascular …, 2007 - academic.oup.com
Objective Congenital loss of function and drug-induced inhibition of the slowly-activating
delayed-rectifier K + current (I Ks ) cause impaired cardiac repolarization. β-Adrenergic-…

High Throughput Measurement of Ca++ Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment …

…, F Cerignoli, R Towart, DJ Gallacher - Toxicological …, 2015 - academic.oup.com
Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are emerging as
a powerful in vitro model for cardiac safety assessment which may allow for better …

[HTML][HTML] Respiratory microbiome of new-born infants

DJ Gallacher, S Kotecha - Frontiers in pediatrics, 2016 - frontiersin.org
The respiratory tract, once believed to be sterile, harbors diverse bacterial communities. The
role of microorganisms within health and disease is slowly being unraveled. Evidence …

Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening?

…, M Cik, P Roevens, A Teisman, DJ Gallacher - … of pharmacological and …, 2009 - Elsevier
The problem of drug-induced hERG channel blockade, which can lead to acquired long QT
syndrome and potentially fatal arrhythmias, has exercised drug developers and regulatory …