User profiles for Lydia J. Finney

Lydia Finney

Senior Clinical Lecturer, Imperial College London
Verified email at imperial.ac.uk
Cited by 1089

[HTML][HTML] Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

LJ Finney, N Glanville, H Farne, J Aniscenko… - Journal of Allergy and …, 2021 - Elsevier
… Author links open overlay panel Lydia J. Finney PhD a , Nicholas Glanville PhD b , Hugo
Farne PhD a , Julia Aniscenko a , Peter Fenwick PhD a , Samuel V. Kemp MD a c , Maria-Belen …

[HTML][HTML] Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

…, RP Walton, LJ Finney, J Aniscenko, J Zhu… - Nature …, 2018 - nature.com
Inhaled corticosteroids (ICS) have limited efficacy in reducing chronic obstructive pulmonary
disease (COPD) exacerbations and increase pneumonia risk, through unknown …

[HTML][HTML] Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease

…, G Radicioni, MT Cross, LJ Finney… - The Journal of …, 2022 - Am Soc Clin Investig
The respiratory tract surface is protected from inhaled pathogens by a secreted layer of mucus
rich in mucin glycoproteins. Abnormal mucus accumulation is a cardinal feature of chronic …

Lower airway colonization and inflammatory response in COPD: a focus on Haemophilus influenzae

LJ Finney, A Ritchie, E Pollard… - International journal of …, 2014 - Taylor & Francis
Bacterial infection of the lower respiratory tract in chronic obstructive pulmonary disease (COPD)
patients is common both in stable patients and during acute exacerbations. The most …

Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease

…, L Cuthbertson, NW Bartlett, LJ Finney… - Science translational …, 2019 - science.org
Bacterial infection commonly complicates inflammatory airway diseases such as chronic
obstructive pulmonary disease (COPD). The mechanisms of increased infection susceptibility …

Chronic obstructive pulmonary disease in sub-Saharan Africa: a systematic review

LJ Finney, JR Feary, J Leonardi-Bee… - … of tuberculosis and …, 2013 - ingentaconnect.com
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major global health
problem. Although COPD is the sixth most common cause of mortality in low- and middle-…

Antiviral immunity is impaired in COPD patients with frequent exacerbations

…, SL Loo, M Calderazzo, LJ Finney… - … of Physiology-Lung …, 2019 - journals.physiology.org
Patients with frequent exacerbations represent a chronic obstructive pulmonary disease (COPD)
subgroup requiring better treatment options. The aim of this study was to determine the …

Human rhinovirus impairs the innate immune response to bacteria in alveolar macrophages in chronic obstructive pulmonary disease

LJ Finney, KBR Belchamber, PS Fenwick… - American Journal of …, 2019 - atsjournals.org
… Correspondence and requests for reprints should be addressed to Lydia J. Finney, MBBCh.,
B.Sc., COPD Research Group, National Heart and Lung Institute, Imperial College, …

A double-blind, randomized, placebo-controlled trial of long-term doxycycline therapy on exacerbation rate in patients with stable chronic obstructive pulmonary …

…, SE Brill, M Law, G Burnside, LJ Finney… - American journal of …, 2023 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) exacerbations are a major
cause of morbidity and mortality, and preventing them is a key treatment target. Long-term …

Repurposing existing drugs for the treatment of COVID-19

H Farne, K Kumar, AI Ritchie, LJ Finney… - Annals of the …, 2020 - atsjournals.org
The rapid global spread and significant mortality associated with the coronavirus disease (COVID-19)
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral …