User profiles for Matthias Griese
Matthias GrieseProfessor of Pediatrics, Hauner Children´s Hospital, University of Munich, Germany Verified email at med.uni-muenchen.de Cited by 23092 |
[HTML][HTML] A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D Mutation
Background Increasing the activity of defective cystic fibrosis transmembrane conductance
regulator (CFTR) protein is a potential treatment for cystic fibrosis. Methods We conducted a …
regulator (CFTR) protein is a potential treatment for cystic fibrosis. Methods We conducted a …
Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
…, LE Mays, M Illenyi, A Schams, M Griese… - Nature …, 2011 - nature.com
Current viral vectors for gene therapy 1 , 2 , 3 are associated with serious safety concerns,
including leukemogenesis 4 , and nonviral vectors are limited by low gene transfer efficiency 5 …
including leukemogenesis 4 , and nonviral vectors are limited by low gene transfer efficiency 5 …
Quantitative and functional impairment of pulmonary CD4+ CD25hi regulatory T cells in pediatric asthma
…, D Reinhardt, T Nicolai, DJ Schendel, M Griese… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Asthma is characterized by a T H 2 immune response. CD4 + CD25 hi
regulatory T cells (Tregs) have been proposed to prevent allergic diseases through suppression …
regulatory T cells (Tregs) have been proposed to prevent allergic diseases through suppression …
Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease
…, D Reinhardt, AA Roscher, D Roos, M Griese - Nature medicine, 2007 - nature.com
Interleukin-8 (IL-8) activates neutrophils via the chemokine receptors CXCR1 and CXCR2.
However, the airways of individuals with cystic fibrosis are frequently colonized by bacterial …
However, the airways of individuals with cystic fibrosis are frequently colonized by bacterial …
The human phenotype ontology in 2021
The Human Phenotype Ontology (HPO, https://hpo.jax.org ) was launched in 2008 to provide
a comprehensive logical standard to describe and computationally analyze phenotypic …
a comprehensive logical standard to describe and computationally analyze phenotypic …
DNAH5 Mutations Are a Common Cause of Primary Ciliary Dyskinesia with Outer Dynein Arm Defects
…, T Nusslein, P Ahrens, M Griese… - American journal of …, 2006 - atsjournals.org
Rationale: Primary ciliary dyskinesia (PCD) is characterized by recurrent airway infections
and randomization of left–right body asymmetry. To date, autosomal recessive mutations have …
and randomization of left–right body asymmetry. To date, autosomal recessive mutations have …
A genome-wide search for linkage to asthma
…, L Jaeger, R Nickel, K Richter, NIM Kjellman, M Griese… - Genomics, 1999 - Elsevier
Asthma is among the most frequent chronic diseases in childhood. Although numerous
environmental risk factors have already been identified, the basis for familial occurrence of …
environmental risk factors have already been identified, the basis for familial occurrence of …
An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome
A Panoskaltsis-Mortari, M Griese… - American journal of …, 2011 - atsjournals.org
Rationale: Acute lung dysfunction of noninfectious etiology, known as idiopathic pneumonia
syndrome (IPS), is a severe complication following hematopoietic stem cell transplantation (…
syndrome (IPS), is a severe complication following hematopoietic stem cell transplantation (…
Efficacy and safety of lumacaftor and ivacaftor in patients aged 6–11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled …
Background Lumacaftor and ivacaftor combination treatment showed efficacy in patients
aged 12 years or older with cystic fibrosis homozygous for F508del-cystic fibrosis …
aged 12 years or older with cystic fibrosis homozygous for F508del-cystic fibrosis …
DYX1C1 is required for axonemal dynein assembly and ciliary motility
DYX1C1 has been associated with dyslexia and neuronal migration in the developing
neocortex. Unexpectedly, we found that deleting exons 2–4 of Dyx1c1 in mice caused a …
neocortex. Unexpectedly, we found that deleting exons 2–4 of Dyx1c1 in mice caused a …