The lung harbours a diverse array of microbes whose dynamic composition is influenced by
both host and environmental factors. Thus far, most studies have described the microbial …

Dietary fiber protects against chronic inflammatory diseases by dampening immune responses
through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in …

Chronic exposure to environmental pollutants is a major contributor to the development and
progression of obstructive airway diseases, including asthma and COPD. Understanding the …

Leptin is an adipocyte-derived hormone, recognized as a critical mediator of the balance
between food intake and energy expenditure by signalling through its functional receptor (Ob-…

The Western world has witnessed a tremendous increase in the occurrence of allergy and
autoimmunity in the second half of the 20th century. Extensive efforts have been made to …

Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired
skin barrier function is linked with enhanced allergen sensitization and the development …

Although obesity is implicated in numerous health complications leading to increased
mortality, the relationship between obesity and outcomes for critically ill patients appears …

Background Early‐life microbial colonization of the skin may modulate the immune system
and impact the development of atopic dermatitis (AD) and allergic diseases later in life. To …

Muscle wasting impairs physical performance, increases mortality and reduces medical
intervention efficacy in chronic diseases and cancer. Developing proficient intervention …

The world is in the midst of an unprecedented epidemic of obesity. This epidemic has changed
the presentation and etiology of common diseases. For example, steatohepatitis, directly …