Indirect effects of the COVID-19 pandemic on paediatric healthcare use and severe disease: a retrospective national cohort study

…, DS Urquhart, B Guthrie, RJ Langley - Archives of disease in …, 2021 - adc.bmj.com
Objectives To determine the indirect consequences of the COVID-19 pandemic on paediatric
healthcare utilisation and severe disease at a national level following lockdown on 23 …

[HTML][HTML] Structure-activity relationships in defensin dimers: a novel link between β-defensin tertiary structure and antimicrobial activity

…, DJ Clarke, NC Polfer, PE Barran, RJ Langley… - Journal of Biological …, 2004 - ASBMB
Defensins are cationic antimicrobial peptides that have a characteristic six-cysteine motif
and are important components of the innate immune system. We recently described a β-…

Is it biologically relevant to measure the structures of small peptides in the gas-phase?

…, DJ Clarke, PRR Langridge-Smith, RJ Langley… - International Journal of …, 2005 - Elsevier
Recent developments in sample introduction of biologically relevant molecules have
heralded a new era for gas-phase methods of structural determination. One of the biggest …

The presumed central nervous system effects of rocuronium in a neonate and its reversal with sugammadex

RJ Langley, J McFadzean… - Pediatric Anesthesia, 2016 - Wiley Online Library
We describe a 2‐day‐old male infant who received rocuronium as part of general anesthesia
for a tracheal esophageal fistula repair. Postoperatively, he had prolonged central and …

[HTML][HTML] Managing patient and clinician expectations of phage therapy in the United Kingdom

…, HJ Stacey, A Brailey, M Suleman, RJ Langley - Antibiotics, 2023 - mdpi.com
Bacteriophage (phage) therapy is a promising alternative antimicrobial approach which has
the potential to transform the way we treat bacterial infections. Phage therapy is currently …

Covalent dimer species of β-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens

…, B McCullough, DJ Clarke, RJ Langley… - Antimicrobial agents …, 2007 - Am Soc Microbiol
Beta defensins comprise a family of cationic, cysteine-rich antimicrobial peptides,
predominantly expressed at epithelial surfaces. Previously we identified a unique five-cysteine …

[HTML][HTML] Phage therapy: Awareness and demand among clinicians in the United Kingdom

EA Simpson, HJ Stacey, RJ Langley, JD Jones - Plos one, 2023 - journals.plos.org
Bacterial resistance or tolerance to antibiotics is costly to patients and healthcare providers.
With the impact of antibiotic resistance forecast to grow, alternative antimicrobial approaches …

Lack of correlation between O-serotype, bacteriophage susceptibility and genomovar status in the Burkholderia cepacia complex

DT Kenna, VA Barcus, RJ Langley… - FEMS Immunology & …, 2003 - academic.oup.com
The Burkholderia cepacia complex comprises at least nine phylogenetically related genomic
species (genomovars) which cause life-threatening infection in immunocompromised …

Characterisation of DEFB107 by mass spectrometry: Lessons from an anti-antimicrobial defensin

…, JA Dorin, A Maxwell, RJ Langley… - International Journal of …, 2006 - Elsevier
Mammalian defensins are small endogenous cationic proteins which form a class of
antimicrobial peptides that is part of the innate immune response of all mammalian species [R. …

Temperate bacteriophages DK4 and BcepMu from Burkholderia cenocepacia J2315 are identical

RJ Langley, D Kenna, J Bartholdson… - FEMS Immunology & …, 2005 - academic.oup.com
The Burkholderia cepacia complex (BCC) comprises at least nine phenotypically similar but
genotypically distinct species (genomovars). Previously recognised as phytopathogens and …